Well, if you want lots of options and stuff - but very VERY high learning curve, then the old-time programmer/hacker's love SoftIce is for you. It's probably like 10 years old, but still the most powerful out there.

That program is so powerful, it can actually run in the background and jump in as windows crashes and give you the opportunity to "fix" whatever went wrong so that windows doesn't crash. It has a very interesting and unique interface that is hard to learn though.
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