I find that atleast running Defrag regularly boosts the read/write time of the drive, and running chkdsk only takes about a minute or so. You don't have to do it every defrag, maybe once a month or so to atleast make sure everything is happy.

Also downloading the S.M.A.R.T utility for your drive manufacturer is a good idea. Just run it when you need it (Hopefully you'll never need it).

Oh one more thing, it doesn't hurt to back up your Registry before installing an exotic piece of hardware or software.
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"Remember how much fun you had shooting spitwads at the teacher in seventh grade? Imagine applying that kind of attitude to actually fucking with Mitsubishi!"
- Jello Biafra